Research Tools | Used by the World’s Best Institutions

 
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The BioCollector™

The BioCollector™ is the industry’s most effective and efficient stool sample collection system for whole stool. Patented patient (donor/user) friendly operation collects whole stool specimens.

The BioCollector™ was specifically designed to provide samples for consistent, standardized, replicable and scalable research.

 

 
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Kit Details
 

Key Features :

  • Easy at home collection of whole stool, improves participant compliance

  • Maintains 4° C to 48 hours in shipping

  • Suitable for collecting stools for genomic, metabolomic, proteomic, and strain isolations

  • Patented system

Key advantages of the full spectrum sample :

  • Multiple identical aliquots for expanded and reproducible research

  • Provides an economically advantageous solution for multiple studies

  • Whole stool eliminates the bias associated with subsampling of partial stool.

For the Donor & Research Facility

  • Whole stool collection enables homogenized, replicates for repeated and expanded research

  • Eliminates “sampling” bias

  • Simple for the participant/patient, no scooping or handling the stool prior to shipping


 
 

Reference Materials

While microbiome research continues to grow exponentially, much of the research today has not used controls such as reference samples or mock communities to standardize data. This has led to a stochastic, non-standardized approaches where data are not readily comparable across published research and results may be impacted by bias is various steps in the process.

The BioCollective, working with DNANexus and Janssen Pharmaceuticals, developed a homogenized whole stool fecal reference sample for their Mosaic Standards Challenge to identify many of the issues of bias that can be introduced in the research.

Leveraging our expertise in whole stool collection, homogenization and processing we are working with NIST to improve industry standards, The BioCollective has developed a line of products to serve as reference materials for research.

These products include:

  • Whole stool fecal reference material, TBC WSFR™

  • Whole stool certified metabolomics reference TBC CMR™

  • Mock Reference Material TBC MRM™

  • Cohort Specific Reference Material TBC CoHo™


Microbiome standards and reference materials will enable federal, academic, and industry labs to reliably reproduce and advance each other's results; thereby enabling the commercial and clinical translation of microbiome science.

 
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“One accurate measurement is worth a thousand expert opinions”

Grace Murray Hopper

Rear Admiral US NAVY


 
TBC Reference Materials
 


Key Features

  • Available in different matrices - DNA/RNA stabilization, lyophilized, glycerol, saline

  • Transport and store at ambient temperature

  • Barcoded for full traceability

  • Standard sample tubes ideal for manual or high-throughput, automated processing

  • Microbial diversity fully representative of the gut microbiome

  • More representative than “mock” communities in aqueous suspensions

  • Broad distribution of Taxa

  • Validated method of fecal homogenization and sample preparation to achieve a consistent microbial profile

  • WGS and 16S reference data from multiple pipelines/kits - Zymo, DNAgenotek, PacBio, IonTorrent


Proposed Composition Health Human Stool Matrix

Component Percent of Total
Water75.0%
Microbial Mass12.5%
Carbohydrates2.3%
Protein1.3%
Lipids1.3%
Fiber6.3%
Bile salts1.0%
Minerals0.5%

 

The BioCRM Partnerships 

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TBC Sample Bank

The BioCollective Sample Bank contains an array of specimens ranging from subjects aged 1 to 102, with a broad diversity of health & lifestyles with metadata for age, sex, medications, diet and more.

Additionally, samples are searchable across data categories including the presence or absence of specific organisms.

 
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Sample Bank Details
 

Key Features

  • Homogenized replicates - allow for work to be repeated and expanded in multiple pipelines from the same sample

  • Multiple aliquots for many uses - genomics, metabolomics, proteomics, isolation and culturing, animal models, etc.

  • Standard method of collection using the BioCollector™ and validated collection process to maintain 4° C temp during transport

  • Validated for isolation and culturing of anaerobes

  • Broad population samples available

    • 50% healthy, as well as cohorts in Parkinson’s, IBD, Crohn’s, Autism, Cancer, Thyroid disease, and more.

  • Metadata - age, sex, medications, diet

  • Metagenomic data available, capability to search by organism

Preparation

  • 1 g neat

  • .2 g neat

  • 1.5 ml cryopreserved in PBS Glycerol